Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MyD88 activation in cardiomyocytes contributes to the heart immune response to acute Trypanosoma cruzi infection with no effect on local parasite control.

PLoS neglected tropical diseases - 1 Aug 2018

Santana Danni Yohani, Salgado Rafael Moysés, Fevereiro Marina, Silva do Nascimento Rogério, Fonseca Raissa, Saraiva Câmara Niels Olsen, Epiphanio Sabrina, Marinho Cláudio Romero Farias, Barreto-Chaves Maria Luiza, D' Império-Lima Maria Regina, Álvarez José M

Abstract excerpt

Cardiomyopathy is the most serious consequence of Chagas disease, a neglected human disorder caused by Trypanosoma cruzi infection. Because T. cruzi parasites invade cardiomyocytes, we sought to investigate whether these cells recognize the parasite in vivo by receptors signaling through the MyD88 adaptor, which mediates the activation pathway of most Toll-like receptors (TLRs) and IL-1/IL-18 receptors, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chagas Cardiomyopathy
Share to Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid Differentiation Factor 88

Share to Myocardium

Share to Myocytes, Cardiac

Share to Selective Estrogen Receptor Modulators

Share to Tamoxifen

Share to Trypanosoma cruzi

Source

Open in PubMed Open full text

Identifiers

PMID: 30067739
DOI: 10.1371/journal.pntd.0006617
PMCID: PMC6089445

Genes

CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MyD88 activation in cardiomyocytes contributes to the heart immune response to acute Trypanosoma cruzi infection with no effect on local parasite control.PMID 30067739Read ↗

Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.Semantic proximity Read ↗

Cardiac and Digestive Forms of Chagas Disease: An Update on Pathogenesis, Genetics, and Therapeutic TargetsSemantic proximity Read ↗

Fat Tissue Regulates the Pathogenesis and Severity of Cardiomyopathy in Murine Chagas DiseaseSemantic proximity Read ↗

MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological OutcomesSemantic proximity Read ↗

The role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiologySemantic proximity Read ↗

Toll-Like Receptors: Are They Taking a Toll on the Heart in Viral Myocarditis?Semantic proximity Read ↗

Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model to Study Trypanosoma cruzi InfectionSemantic proximity Read ↗

Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heartSemantic proximity Read ↗

Chagasic cardiomyopathy, from acute to chronic: is this mediated by host susceptibility factors?Semantic proximity Read ↗

Chagas Disease Cardiomyopathy: Immunopathology and GeneticsSemantic proximity Read ↗

Gene Expression Changes Associated with Myocarditis and Fibrosis in Hearts of Mice with Chronic Chagasic CardiomyopathySemantic proximity Read ↗

Overexpression of myeloid differentiation protein 88 in mice induces mild cardiac dysfunction, but no deficit in heart morphology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.