Article

Deletion of cytoplasmic β/γ-actin in the mouse heart protects from disease by augmenting sarcolemma stability

2026-07-27

Abstract excerpt

The actin cytoskeleton of the cardiomyocyte is organized into two structurally and functionally distinct filament networks. The sarcomeric thin filaments, built primarily from cardiac α-actin (αCA), generate contractile force, whereas a separate subsarcolemmal cytoplasmic network, built from β-actin ( Actb gene) and γ-actin ( Actg1 gene), lies beneath the sarcolemma and is comparatively understudied in the matur...

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Literature Corpus work: 8304ebb0-f112-5554-ac0a-d0c0602a099b
DOI: 10.64898/2026.07.24.740593

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