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Article

Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.

Circulation research - 23 Oct 2009

Blyszczuk Przemyslaw, Kania Gabriela, Dieterle Thomas, Marty Rene R, Valaperti Alan, Berthonneche Corinne, Pedrazzini Thierry, Berger Christoph T, Dirnhofer Stephan, Matter Christian M, Penninger Josef M, Lüscher Thomas F, Eriksson Urs

Abstract excerpt

RATIONALE: The myeloid differentiation factor (MyD)88/interleukin (IL)-1 axis activates self-antigen-presenting cells and promotes autoreactive CD4(+) T-cell expansion in experimental autoimmune myocarditis, a mouse model of inflammatory heart disease. OBJECTIVE: The aim of this study was to determine the role of MyD88 and IL-1 in the progression of acute myocarditis to an end-stage heart failure. METHODS AND...

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Source

Identifiers

PMID: 19762681
DOI: 10.1161/CIRCRESAHA.109.199802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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