Article

Neutrophil Peptidylarginine Deiminase 4 is Essential for Detrimental Age-related Cardiac Remodeling & Dysfunction in Mice

2022-03-14

Abstract excerpt

<h4>Aims</h4> We aimed to study the long-term effect of neutrophils on cardiac health during the process of natural aging. We hypothesized that neutrophil PAD4, via its role in neutrophil extracellular trap (NET) formation, is involved in myocardial remodeling and cardiac fibrosis development, resulting in turn in impaired cardiac function. <h4>Methods and results</h4> We generated mice with deletion of Padi4 ,...

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Literature Corpus work: 7abfc271-8898-5fd2-973c-514b16343b4d
DOI: 10.1101/2022.03.14.484062

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