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Article

LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling.

Basic research in cardiology - 21 Aug 2018

DeLeon-Pennell Kristine Y, Mouton Alan J, Ero Osasere K, Ma Yonggang, Padmanabhan Iyer Rugmani, Flynn Elizabeth R, Espinoza Ingrid, Musani Solomon K, Vasan Ramachandran S, Hall Michael E, Fox Ervin R, Lindsey Merry L

Abstract excerpt

Sex differences in heart failure development following myocardial infarction (MI) are not fully understood. We hypothesized that differential MI signaling could explain variations in outcomes. Analysis of the mouse heart attack research tool 1.0 (422 mice; young = 5.4 ± 0.1; old = 23.3 ± 0.1 months of age) was used to dissect MI signaling pathways, which was validated in a new cohort of mice (4.8 ± 0.2 months of...

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Identifiers

PMID: 30132266
DOI: 10.1007/s00395-018-0699-5
PMCID: PMC6105266

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