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Article

The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice

2 Jan 2008

Abstract excerpt

The adult heart responds to excessive neurohumoral signaling and workload by a pathological growth response characterized by hypertrophy of cardiomyocytes and activation of a fetal program of cardiac gene expression. These responses culminate in diminished pump function, ventricular dilatation, wall thinning, and fibrosis, and can result in sudden death. Myocyte enhancer factor-2 (MEF2) transcription factors...

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Identifiers

PMID: 18079970
DOI: 10.1172/jci33255

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