Article

Drp1-mediated mitochondrial fission protects macrophages from mtDNA/ZBP1-mediated sterile inflammation and inhibits post-infarct cardiac remodeling

2024-10-19

Abstract excerpt

<h4>Background</h4> Ischemic heart disease is a leading cause of death worldwide, and heart failure after myocardial infarction (MI) is a growing issue in this aging society. Macrophages play central roles in left ventricular (LV) remodeling after MI. Mitochondria consistently change their morphology, including fission and fusion, but the role of these mitochondrial morphological changes, especially in macrophage...

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Literature Corpus work: e33632fc-77a8-5181-a8ab-347eb7fbde4b
DOI: 10.1101/2024.10.18.619173

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