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Article

Intrahaplotypic Variants Differentiate Complex Linkage Disequilibrium within Human MHC Haplotypes.

Scientific reports - 23 Nov 2015

Lam Tze Hau, Tay Matthew Zirui, Wang Bei, Xiao Ziwei, Ren Ee Chee

Abstract excerpt

Distinct regions of long-range genetic fixation in the human MHC region, known as conserved extended haplotypes (CEHs), possess unique genomic characteristics and are strongly associated with numerous diseases. While CEHs appear to be homogeneous by SNP analysis, the nature of fine variations within their genomic structure is unknown. Using multiple, MHC-homozygous cell lines, we demonstrate extensive sequence...

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Share to Chromosomes, Human, Pair 6
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Genetic Loci

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Source

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Identifiers

PMID: 26593880
DOI: 10.1038/srep16972
PMCID: PMC4655331

Genes

ZFP57

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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