Article
A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.
American journal of human genetics - 1 Apr 2005
Miretti Marcos M, Walsh Emily C, Ke Xiayi, Delgado Marcos, Griffiths Mark, Hunt Sarah, Morrison Jonathan, Whittaker Pamela, Lander Eric S, Cardon Lon R, Bentley David R, Rioux John D, Beck Stephan, Deloukas Panos
Abstract excerpt
Autoimmune, inflammatory, and infectious diseases present a major burden to human health and are frequently associated with loci in the human major histocompatibility complex (MHC). Here, we report a high-resolution (1.9 kb) linkage-disequilibrium (LD) map of a 4.46-Mb fragment containing the MHC in U.S. pedigrees with northern and western European ancestry collected by the Centre d'Etude du Polymorphisme Humain...
Read the complete abstract on PubMedTopics
- Haplotypes
- Humans
- Linkage Disequilibrium
- Major Histocompatibility Complex
- Polymorphism, Single Nucleotide