Article
Recombination and mutation shape variations in the major histocompatibility complex.
Journal of genetics and genomics = Yi chuan xue bao - 1 Dec 2022
Sun Yuying, Yuan Fang, Wang Ling, Dai Dongfa, Zhang Zhijian, Liang Fei, Liu Nan, Long Juan, Zhao Xiao, Xi Yongzhi
Abstract excerpt
The major histocompatibility complex (MHC) is closely associated with numerous diseases, but its high degree of polymorphism complicates the discovery of disease-associated variants. In principle, recombination and de novo mutations are two critical factors responsible for MHC polymorphisms. However, direct evidence for this hypothesis is lacking. Here, we report the generation of fine-scale MHC recombination and...
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