Article

Structural variation shapes regulatory and evolutionary diversity at the HLA locus

2026-04-24

Abstract excerpt

The human leukocyte antigen (HLA) region is among the most polymorphic loci in the human genome and plays a central role in immune function, yet the contribution of structural variation to its genetic and regulatory diversity remains poorly characterised. Using 460 phased, near-complete human genome assemblies from globally diverse populations, we systematically mapped structural variation and gene content across...

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Literature Corpus work: ef34c9e1-76c8-5cb3-9032-a32db21a52aa
DOI: 10.64898/2026.04.23.720469

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