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Article

Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC.

Human molecular genetics - 15 Mar 2003

Ahmad Tariq, Neville Matt, Marshall Sara E, Armuzzi Alessandro, Mulcahy-Hawes Kim, Crawshaw Jonathan, Sato Hiroe, Ling Khoon-Lin, Barnardo Martin, Goldthorpe Sue, Walton Robert, Bunce Mike, Jewell Derek P, Welsh Ken I

Abstract excerpt

Detailed knowledge of linkage disequilibrium (LD) is regarded as a prerequisite for population-based disease gene mapping. Variable patterns across the human genome are now recognized, both between regions and populations. Here, we demonstrate that LD may also vary within a genomic region in a haplotype-specific manner. In 864 Caucasian unrelated individuals, we describe haplotype-specific LD patterns across the...

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PMID: 12620970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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