Article
MutationAligner: a resource of recurrent mutation hotspots in protein domains in cancer.
Nucleic acids research - 4 Jan 2016
Gauthier Nicholas Paul, Reznik Ed, Gao Jianjiong, Sumer Selcuk Onur, Schultz Nikolaus, Sander Chris, Miller Martin L
Abstract excerpt
The MutationAligner web resource, available at http://www.mutationaligner.org, enables discovery and exploration of somatic mutation hotspots identified in protein domains in currently (mid-2015) more than 5000 cancer patient samples across 22 different tumor types. Using multiple sequence alignments of protein domains in the human genome, we extend the principle of recurrence analysis by aggregating mutations in...
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