Article

A full-proteome, interaction-specific characterization of mutational hotspots across human cancers

2019-12-21

Abstract excerpt

Rapid accumulation of cancer genomic data has led to the identification of an increasing number of mutational hotspots with uncharacterized significance. Here we present a biologically-informed computational framework that characterizes the functional relevance of all 1,107 published mutational hotspots identified in ∼25,000 tumor samples across 41 cancer types in the context of a human 3D interactome network, in...

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Literature Corpus work: c46c4059-6784-5cbc-b9a7-1f4b736678c4
DOI: 10.1101/2019.12.20.885293

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