Article
Sequence and structure signatures of cancer mutation hotspots in protein kinases.
PloS one - 16 Oct 2009
Dixit Anshuman, Yi Lin, Gowthaman Ragul, Torkamani Ali, Schork Nicholas J, Verkhivker Gennady M
Abstract excerpt
Protein kinases are the most common protein domains implicated in cancer, where somatically acquired mutations are known to be functionally linked to a variety of cancers. Resequencing studies of protein kinase coding regions have emphasized the importance of sequence and structure determinants of cancer-causing kinase mutations in understanding of the mutation-dependent activation process. We have developed an...
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