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Article

Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples.

PLoS computational biology - 1 Apr 2017

Peterson Thomas A, Gauran Iris Ivy M, Park Junyong, Park DoHwan, Kann Maricel G

Abstract excerpt

The fight against cancer is hindered by its highly heterogeneous nature. Genome-wide sequencing studies have shown that individual malignancies contain many mutations that range from those commonly found in tumor genomes to rare somatic variants present only in a small fraction of lesions. Such rare somatic variants dominate the landscape of genomic mutations in cancer, yet efforts to correlate somatic mutations...

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PMID: 28426665
DOI: 10.1371/journal.pcbi.1005428
PMCID: PMC5398485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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