Article
Protein-structure-guided discovery of functional mutations across 19 cancer types.
Nature genetics - 1 Aug 2016
Niu Beifang, Scott Adam D, Sengupta Sohini, Bailey Matthew H, Batra Prag, Ning Jie, Wyczalkowski Matthew A, Liang Wen-Wei, Zhang Qunyuan, McLellan Michael D, Sun Sam Q, Tripathi Piyush, Lou Carolyn, Ye Kai, Mashl R Jay, Wallis John, Wendl Michael C, Chen Feng, Ding Li
Abstract excerpt
Local concentrations of mutations are well known in human cancers. However, their three-dimensional spatial relationships in the encoded protein have yet to be systematically explored. We developed a computational tool, HotSpot3D, to identify such spatial hotspots (clusters) and to interpret the potential function of variants within them. We applied HotSpot3D to >4,400 TCGA tumors across 19 cancer types,...
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