Article
A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.
Genome research - 1 Jan 2022
Chen Siwei, Liu Yuan, Zhang Yingying, Wierbowski Shayne D, Lipkin Steven M, Wei Xiaomu, Yu Haiyuan
Abstract excerpt
Rapid accumulation of cancer genomic data has led to the identification of an increasing number of mutational hotspots with uncharacterized significance. Here we present a biologically informed computational framework that characterizes the functional relevance of all 1107 published mutational hotspots identified in approximately 25,000 tumor samples across 41 cancer types in the context of a human 3D interactome...
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