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Article

Systematic characterization of pan-cancer mutation clusters.

Molecular systems biology - 23 Mar 2018

Buljan Marija, Blattmann Peter, Aebersold Ruedi, Boutros Michael

Abstract excerpt

Cancer genome sequencing has shown that driver genes can often be distinguished not only by the elevated mutation frequency but also by specific nucleotide positions that accumulate changes at a high rate. However, properties associated with a residue's potential to drive tumorigenesis when mutated have not yet been systematically investigated. Here, using a novel methodological approach, we identify and...

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Identifiers

PMID: 29572294
DOI: 10.15252/msb.20177974
PMCID: PMC5866917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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