Article
Identification and analysis of mutational hotspots in oncogenes and tumour suppressors.
Oncotarget - 28 Mar 2017
Baeissa Hanadi, Benstead-Hume Graeme, Richardson Christopher J, Pearl Frances M G
Abstract excerpt
BACKGROUND: The key to interpreting the contribution of a disease-associated mutation in the development and progression of cancer is an understanding of the consequences of that mutation both on the function of the affected protein and on the pathways in which that protein is involved. Protein domains encapsulate function and position-specific domain based analysis of mutations have been shown to help elucidate...
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