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Article

Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types.

BMC genomics - 23 Jun 2016

Chen Tenghui, Wang Zixing, Zhou Wanding, Chong Zechen, Meric-Bernstam Funda, Mills Gordon B, Chen Ken

Abstract excerpt

BACKGROUND: An important step towards personalizing cancer treatment is to integrate heterogeneous evidences to catalog mutational hotspots that are biologically and therapeutically relevant and thus represent where targeted therapy would likely be beneficial. However, existing methods do not sufficiently delineate varying functionality of individual mutations within the same genes. RESULTS: We observed a large...

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Identifiers

PMID: 27356755
DOI: 10.1186/s12864-016-2727-x
PMCID: PMC4928158

Genes

GATA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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