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Identification of coding and non-coding mutational hotspots in cancer genomes.

BMC genomics - 5 Jan 2017

Piraino Scott W, Furney Simon J

Abstract excerpt

BACKGROUND: The identification of mutations that play a causal role in tumour development, so called "driver" mutations, is of critical importance for understanding how cancers form and how they might be treated. Several large cancer sequencing projects have identified genes that are recurrently mutated in cancer patients, suggesting a role in tumourigenesis. While the landscape of coding drivers has been...

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PMID: 28056774
DOI: 10.1186/s12864-016-3420-9
PMCID: PMC5217664

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