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Article

ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination

19 Nov 2015

Abstract excerpt

We generate a mouse model for the human microcephaly syndrome by mutating the ASPM locus, and demonstrate a premature exhaustion of the neuronal progenitor pool due to dysfunctional self-renewal processes. Earlier studies have linked ASPM mutant progenitor excessive cell cycle exit to a mitotic orientation defect. Here, we demonstrate a mitotic orientation-independent effect of ASPM on cell cycle duration. We...

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PMID: 26581405
DOI: 10.1038/ncomms9763

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ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitinationPMID 26581405Read ↗

The microcephaly gene <i>ASPM</i> is required for the timely generation of human outer-radial glia progenitors by controlling mitotic spindle orientationSemantic proximity Read ↗

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Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2Semantic proximity Read ↗

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Extra‐cell cycle regulatory functions of cyclin‐dependent kinases (<scp>CDK</scp>) and <scp>CDK</scp> inhibitor proteins contribute to brain development and neurological disordersSemantic proximity Read ↗

Oncogenic ASPM Is a Regulatory Hub of Developmental and Stemness Signaling in CancersSemantic proximity Read ↗

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