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Article

Loss of symmetric cell division of apical neural progenitors drives<i>DENND5A</i>-related developmental and epileptic encephalopathy

2022-08-26

Abstract excerpt

Developmental and epileptic encephalopathies (DEEs) are a heterogenous group of epilepsies in which altered brain development leads to developmental delay and seizures, with the epileptic activity further negatively impacting neurodevelopment. Identifying the underlying cause of DEEs is essential for progress toward precision therapies. Here we describe a group of individuals with biallelic variants in DENND5A and...

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Literature Corpus work
a1c4f74d-ae44-5449-babb-e1f5bb1a9222
DOI
10.1101/2022.08.23.22278845
Open publication

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Loss of symmetric cell division of apical neural progenitors drives<i>DENND5A</i>-related developmental and epileptic encephalopathyDOI 10.1101/2022.08.23.22278845
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