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Article

Human ASPM participates in spindle organisation, spindle orientation and cytokinesis.

BMC cell biology - 2 Nov 2010

Higgins Julie, Midgley Carol, Bergh Anna-Maria, Bell Sandra M, Askham Jonathan M, Roberts Emma, Binns Ruth K, Sharif Saghira M, Bennett Christopher, Glover David M, Woods C Geoffrey, Morrison Ewan E, Bond Jacquelyn

Abstract excerpt

BACKGROUND: Mutations in the Abnormal Spindle Microcephaly related gene (ASPM) are the commonest cause of autosomal recessive primary microcephaly (MCPH) a disorder characterised by a small brain and associated mental retardation. ASPM encodes a mitotic spindle pole associated protein. It is sugg...

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Source

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Identifiers

PMID: 21044324
DOI: 10.1186/1471-2121-11-85
PMCID: PMC2988714

Genes

ASPM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21044324-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Human ASPM participates in spindle organisation, spindle orientation and cytokinesis.PMID 21044324Read ↗

Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2Semantic proximity Read ↗

The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.Semantic proximity Read ↗

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.Semantic proximity Read ↗

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and developmentSemantic proximity Read ↗

The microcephaly gene <i>ASPM</i> is required for the timely generation of human outer-radial glia progenitors by controlling mitotic spindle orientationSemantic proximity Read ↗

Microcephaly-associated genes asp and Sas4 influence chromatin organization and nuclear lamina structure in Drosophila melanogaster.Semantic proximity Read ↗

Autosomal recessive primary microcephaly due to ASPM mutations: An update.Semantic proximity Read ↗

An Asp-CaM complex is required for centrosome-pole cohesion and centrosome inheritance in neural stem cells.Semantic proximity Read ↗

ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitinationSemantic proximity Read ↗

Autosomal Recessive Primary Microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum.Semantic proximity Read ↗

Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle.Semantic proximity Read ↗

Microcephaly-Associated Genes <i>asp</i> and <i>Sas4</i> Control Chromatin Organization and Nuclear Lamina Structure in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

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