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Article

SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis.

eLife - 17 Nov 2020

Atkins Alisa, Xu Michelle J, Li Maggie, Rogers Nathaniel P, Pryzhkova Marina V, Jordan Philip W

Abstract excerpt

Mutations of SMC5/6 components cause developmental defects, including primary microcephaly. To model neurodevelopmental defects, we engineered a mouse wherein Smc5 is conditionally knocked out (cKO) in the developing neocortex. Smc5 cKO mice exhibited neurodevelopmental defects due to neural progenitor cell (NPC) apoptosis, which led to reduction in cortical layer neurons. Smc5 cKO NPCs formed DNA bridges during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33200984
DOI: 10.7554/eLife.61171
PMCID: PMC7723410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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