Extra‐cell cycle regulatory functions of cyclin‐dependent kinases (<scp>CDK</scp>) and <scp>CDK</scp> inhibitor proteins contribute to brain development and neurological disorders

Abstract excerpt

In developing brains, neural progenitors exhibit cell cycle-dependent nuclear movement within the ventricular zone [interkinetic nuclear migration (INM)] and actively proliferate to produce daughter progenitors and/or neurons, whereas newly generated neurons exit from the cell cycle and begin pial surface-directed migration and maturation. Dysregulation of the balance between the proliferation and the cell cycle...

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