Article

The microcephaly gene <i>ASPM</i> is required for the timely generation of human outer-radial glia progenitors by controlling mitotic spindle orientation

2023-09-25

Abstract excerpt

<h4>Summary</h4> Abnormal spindle-like, microcephaly-associated ( ASPM ) is the most commonly mutated gene in primary microcephaly (MCPH), characterized by reduced brain size and intellectual deficiency. The mechanisms underlying MCPH have remained unclear, as ASPM disruption leads to distinct phenotypes depending on the species studied. Here, we studied the impact of ASPM pathogenic mutations on human cortico...

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Literature Corpus work: f2ddce02-810c-527a-a5f3-dd34bc0ecfe3
DOI: 10.1101/2023.09.25.559314

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