Article
Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.
Proceedings of the National Academy of Sciences of the United States of America - 21 Sept 2010
Pulvers Jeremy N, Bryk Jarosław, Fish Jennifer L, Wilsch-Bräuninger Michaela, Arai Yoko, Schreier Dora, Naumann Ronald, Helppi Jussi, Habermann Bianca, Vogt Johannes, Nitsch Robert, Tóth Attila, Enard Wolfgang, Pääbo Svante, Huttner Wieland B
Abstract excerpt
Mutations in ASPM (abnormal spindle-like microcephaly associated) cause primary microcephaly in humans, a disorder characterized by a major reduction in brain size in the apparent absence of nonneurological anomalies. The function of the Aspm protein in neural progenitor cell expansion, as well a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.