Article

Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2

2017-01-22

Abstract excerpt

Nonsense mutations in the ASPM gene have been most frequently identified among familial microcephaly patients. Depletion of the Drosophila orthologue causes spindle pole unfocusing during mitosis in multiple cell types. However, it remains unknown whether human ASPM has a similar function. Here, using CRISPR-based gene knockout (KO) and RNA interference combined with auxin-inducible degron, we show that ASPM fun...

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Literature Corpus work: 2806f375-2598-5b26-9524-f25051e4a7a4
DOI: 10.1101/102236

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