Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic ASPM Is a Regulatory Hub of Developmental and Stemness Signaling in Cancers

29 Jun 2023

Abstract excerpt

Despite recent advances in molecularly targeted therapies and immunotherapies, the effective treatment of advanced-stage cancers remains a largely unmet clinical need. Identifying driver mechanisms of cancer aggressiveness can lay the groundwork for the development of breakthrough therapeutic strategies. Assembly factor for spindle microtubules (ASPM) was initially identified as a centrosomal protein that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Epigenetics and DNA Methylation
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37384617
DOI: 10.1158/0008-5472.can-23-0158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic ASPM Is a Regulatory Hub of Developmental and Stemness Signaling in CancersPMID 37384617Read ↗

The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosisSemantic proximity Read ↗

SPC25 promotes proliferation and stemness of hepatocellular carcinoma cells via the DNA-PK/AKT/Notch1 signaling pathwaySemantic proximity Read ↗

STNM1 in human cancers: role, function and potential therapy sensitizerSemantic proximity Read ↗

Pan-cancer analysis reveals nucleolar and spindle-associated protein 1 as a predictive marker for human cancerSemantic proximity Read ↗

Identification of the ASPM-miR-26b-5p network associated with the aggressive traits of HCC cellsSemantic proximity Read ↗

ASPM and TROAP gene expression as potential malignant tumor markersSemantic proximity Read ↗

The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.Semantic proximity Read ↗

Moonlighting Role of Meiotic SYCP1 in Breast Cancer: A Chromatin-Bound Regulator of DNA Repair, Transcription, and Drug ResistanceSemantic proximity Read ↗

FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation and lethality in glioblastoma and other cancersSemantic proximity Read ↗

Single-cell and bulk RNA sequencing analysis reveals CENPA as a potential biomarker and therapeutic target in cancersSemantic proximity Read ↗

Stathmin: a protein with many tasks. New biomarker and potential target in cancerSemantic proximity Read ↗

ASPM Activates Hedgehog and Wnt Signaling to Promote Small Cell Lung Cancer Stemness and ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.