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Article

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.

Neuron - 23 Nov 2016

Jayaraman Divya, Kodani Andrew, Gonzalez Dilenny M, Mancias Joseph D, Mochida Ganeshwaran H, Vagnoni Cristiana, Johnson Jeffrey, Krogan Nevan, Harper J Wade, Reiter Jeremy F, Yu Timothy W, Bae Byoung-Il, Walsh Christopher A

Abstract excerpt

Mutations in several genes encoding centrosomal proteins dramatically decrease the size of the human brain. We show that Aspm (abnormal spindle-like, microcephaly-associated) and Wdr62 (WD repeat-containing protein 62) interact genetically to control brain size, with mice lacking Wdr62, Aspm, or both showing gene dose-related centriole duplication defects that parallel the severity of the microcephaly and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27974163
DOI: 10.1016/j.neuron.2016.09.056
PMCID: PMC5199216

Genes

CPAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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