Article
The exon junction complex component Magoh controls brain size by regulating neural stem cell division.
Nature neuroscience - 1 May 2010
Silver Debra L, Watkins-Chow Dawn E, Schreck Karisa C, Pierfelice Tarran J, Larson Denise M, Burnetti Anthony J, Liaw Hung-Jiun, Myung Kyungjae, Walsh Christopher A, Gaiano Nicholas, Pavan William J
Abstract excerpt
Brain structure and size require precise division of neural stem cells (NSCs), which self-renew and generate intermediate neural progenitors (INPs) and neurons. The factors that regulate NSCs remain poorly understood, and mechanistic explanations of how aberrant NSC division causes the reduced brain size seen in microcephaly are lacking. Here we show that Magoh, a component of the exon junction complex (EJC) that...
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