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Article

Effects of Mutations on the Reconfiguration Rate of α-Synuclein.

The journal of physical chemistry. B - 17 Dec 2015

Acharya Srabasti, Saha Shreya, Ahmad Basir, Lapidus Lisa J

Abstract excerpt

It is still poorly understood why α-synuclein, the intrinsically disordered protein involved in Parkinson's and other neurodegenerative diseases, is so prone to aggregation. Recent work has shown a correlation between the aggregation rate and the rate of diffusional reconfiguration by varying temperature and pH. Here we examine the effects of several point mutations in the sequence on the conformational ensemble...

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Identifiers

PMID: 26572968
DOI: 10.1021/acs.jpcb.5b10136
PMCID: PMC4836914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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