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Article

Perturbation in Long-Range Contacts Modulates the Kinetics of Amyloid Formation in α-Synuclein Familial Mutants.

ACS chemical neuroscience - 18 Oct 2017

Ranjan Priyatosh, Kumar Ashutosh

Abstract excerpt

The characteristic cross-β-sheet-rich amyloid fibril formation by intrinsically disordered α-synuclein proteins is one of the pathological hallmarks of Parkinson's disease. Although unstructured in solution, the presence of autoinhibitory long-range contacts in monomeric form prevents protein aggregation. Out of the various factors that affect the rate of amyloid formation, familial mutations play an important...

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PMID: 28759722
DOI: 10.1021/acschemneuro.7b00149

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