Article
The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils.
ACS nano - 26 May 2020
Ruggeri Francesco Simone, Flagmeier Patrick, Kumita Janet R, Meisl Georg, Chirgadze Dimitri Y, Bongiovanni Marie N, Knowles Tuomas P J, Dobson Christopher M
Abstract excerpt
Proteinaceous deposits of α-synuclein amyloid fibrils are a hallmark of human disorders including Parkinson's disease. The onset of this disease is also associated with five familial mutations of the gene encoding the protein. However, the mechanistic link between single point mutations and the kinetics of aggregation, biophysical properties of the resulting amyloid fibrils, and an increased risk of disease is...
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