Article
Familial Mutations May Switch Conformational Preferences in α-Synuclein Fibrils.
ACS chemical neuroscience - 19 Apr 2017
Xu Liang, Ma Buyong, Nussinov Ruth, Thompson Damien
Abstract excerpt
The pathogenesis of Parkinson's disease is closely associated with the aggregation of the α-synuclein protein. Several familial mutants have been identified and shown to affect the aggregation kinetics of α-synuclein through distinct molecular mechanisms. Quantitative evaluation of the relative stabilities of the wild type and mutant fibrils is crucial for understanding the aggregation process and identifying the...
Topics
Join the communities discussing this publication.