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Combined Effects of Mutation and Ionic Strength on α-Synuclein Reveal Generic Features of Aggregation-Prone Monomeric States.

ACS chemical neuroscience - 15 Jul 2026

Tammara Vaishnavi, Das Ankita, Desai Zion, Das Atanu

Abstract excerpt

α-Synuclein (αS) is a highly charged, intrinsically disordered protein (IDP) whose aberrant aggregation is linked to Parkinson's disease (PD). Along with wild-type (WT) αS, five single-point mutants (A30P, E46K, H50Q, G51D, and A53T) are implicated in familial PD. To resolve contradictory experimental observations under varying solution conditions, we investigated how ionic strength modulates the relative...

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PMID: 42411659
DOI: 10.1021/acschemneuro.6c00439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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