Article
The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.
The Journal of biological chemistry - 23 Jan 2015
Porcari Riccardo, Proukakis Christos, Waudby Christopher A, Bolognesi Benedetta, Mangione P Patrizia, Paton Jack F S, Mullin Stephen, Cabrita Lisa D, Penco Amanda, Relini Annalisa, Verona Guglielmo, Vendruscolo Michele, Stoppini Monica, Tartaglia Gian Gaetano, Camilloni Carlo, Christodoulou John, Schapira Anthony H V, Bellotti Vittorio
Abstract excerpt
The conversion of α-synuclein from its intrinsically disordered monomeric state into the fibrillar cross-β aggregates characteristically present in Lewy bodies is largely unknown. The investigation of α-synuclein variants causative of familial forms of Parkinson disease can provide unique insights into the conditions that promote or inhibit aggregate formation. It has been shown recently that a newly identified...
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