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Article

Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2016

Schwanekamp Jennifer A, Lorts Angela, Vagnozzi Ronald J, Vanhoutte Davy, Molkentin Jeffery D

Abstract excerpt

OBJECTIVE: Periostin is a secreted protein that can alter extracellular matrix remodeling in response to tissue injury. However, the functional role of periostin in the development of atherosclerotic plaques has yet to be described despite its observed induction in diseased vessels and presence in the serum. APPROACH AND RESULTS: Hyperlipidemic, apolipoprotein E-null mice (ApoE(-/) (-)) were crossed with...

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Source

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Identifiers

PMID: 26564821
DOI: 10.1161/ATVBAHA.115.306397
PMCID: PMC4690815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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