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Article

PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement.

Atherosclerosis - 1 Oct 2016

Ferri Nicola, Marchianò Silvia, Tibolla Gianpaolo, Baetta Roberta, Dhyani Ashish, Ruscica Massimiliano, Uboldi Patrizia, Catapano Alberico L, Corsini Alberto

Abstract excerpt

BACKGROUND AND AIMS: Proprotein convertase subtilisin kexin type 9 (PCSK9) induces degradation of the low-density lipoprotein-receptor (LDLR). Smooth muscle cells (SMCs) in human atherosclerotic plaques and cultured SMCs express PCSK9. The present study aimed at defining the role of PCSK9 on vascular response to injury. METHODS: Carotid neointimal lesions were induced by positioning a non-occlusive collar in...

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Source

Identifiers

PMID: 27477186
DOI: 10.1016/j.atherosclerosis.2016.07.910

Genes

PCSK9
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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