Article
Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic.
The Journal of pathology - 1 Nov 2006
Lutgens S P M, Kisters N, Lutgens E, van Haaften R I M, Evelo C T A, de Winther M P J, Saftig P, Daemen M J A P, Heeneman S, Cleutjens K B J M
Abstract excerpt
Recently, we showed that cathepsin K deficiency reduces atherosclerotic plaque progression, induces plaque fibrosis, but aggravates macrophage foam cell formation in the ApoE -/- mouse. To obtain more insight into the molecular mechanisms by which cathepsin K disruption evokes the observed phenotypic changes, we used microarray analysis for gene expression profiling of aortic arches of CatK -/-/ApoE -/- and ApoE...
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