Article
Common variants in the periostin gene influence development of atherosclerosis in young persons.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2011
Hixson James E, Shimmin Lawrence C, Montasser May E, Kim Do-Kyun, Zhong Yu, Ibarguen Heladio, Follis Jack, Malcom Gray, Strong Jack, Howard Tim, Langefeld Carl, Liu Yongmei, Rotter Jerome I, Johnson Craig, Herrington David
Abstract excerpt
OBJECTIVE: We investigated the influence of genetic variants (rare and common) in the gene encoding periostin (POSTN) on atherosclerosis as measured in arterial specimens from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. METHODS AND RESULTS: A comprehensive survey of common POSTN variants (87 single-nucleotide polymorphisms [SNPs]) in PDAY subjects (n = 2527) identified numerous SNPs...
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