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Article

Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease

2 Sept 2009

Abstract excerpt

The Postn gene encodes protein periostin. During embryonic development, it is highly expressed in the outflow tract (OFT) endocardial cushions of the developing heart, which give rise to several structures of the mature heart including the aortic valve. Periostin was previously implicated in osteoblast differentiation, cancer metastasis, and tooth and bone development, but its role in cardiac OFT development is...

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Share to Cardiac Fibrosis and Remodeling
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Identifiers

PMID: 19723774
DOI: 10.1152/physiolgenomics.00078.2009

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