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Article

Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling.

Circulation research - 3 Aug 2007

Oka Toru, Xu Jian, Kaiser Robert A, Melendez Jaime, Hambleton Michael, Sargent Michelle A, Lorts Angela, Brunskill Eric W, Dorn Gerald W, Conway Simon J, Aronow Bruce J, Robbins Jeffrey, Molkentin Jeffery D

Abstract excerpt

The cardiac extracellular matrix is a dynamic structural support network that is both influenced by, and a regulator of, pathological remodeling and hypertrophic growth. In response to pathologic insults, the adult heart reexpresses the secreted extracellular matrix protein periostin (Pn). Here w...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17569887
DOI: 10.1161/CIRCRESAHA.107.149047
PMCID: PMC2680305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17569887-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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