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Article

Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model.

Atherosclerosis - 1 Jul 2018

Nahon Joya E, Hoekstra Menno, Havik Stefan R, Van Santbrink Peter J, Dallinga-Thie Geesje M, Kuivenhoven Jan-Albert, Geerling Janine J, Van Eck Miranda

Abstract excerpt

BACKGROUND AND AIMS: Proteoglycan 4 (Prg4) has a high structural similarity with the established atherosclerosis-modulating proteoglycan versican, but its role in atherogenesis is still unknown. Therefore, the impact of Prg4 deficiency on macrophage function in vitro and atherosclerosis susceptibility in vivo was investigated. METHODS: The presence and localization of Prg4 was studied in atherosclerotic lesions....

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PMID: 29772480
DOI: 10.1016/j.atherosclerosis.2018.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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