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Article

A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2011

Johnson Jason L, Devel Laurent, Czarny Bertrand, George Sarah J, Jackson Christopher L, Rogakos Vassilis, Beau Fabrice, Yiotakis Athanasios, Newby Andrew C, Dive Vincent

Abstract excerpt

OBJECTIVE: Matrix metalloproteinase (MMP)-12 has been implicated in plaque progression and instability and is also amenable to selective inhibition. In this study, we investigated the influence of a greater than 10-fold selective synthetic MMP-12 inhibitor on plaque progression in the apolipoprotein E knockout mouse model of atherosclerosis. METHODS AND RESULTS: A phosphinic peptide (RXP470.1) that is a potent,...

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Identifiers

PMID: 21212406
DOI: 10.1161/ATVBAHA.110.219147
PMCID: PMC3041652

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Source receipt: pubmed, retrieved 7 Sept 2026.

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