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Article

APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults.

Scientific reports - 10 Nov 2015

Shine J P, Hodgetts C J, Postans M, Lawrence A D, Graham K S

Abstract excerpt

Apolipoprotein E (APOE) ε4 is a major genetic risk factor for Alzheimer's disease (AD), yet the mechanisms by which APOE-ε4 influences early-life brain function, and hence, in turn, risk for later-life AD, are poorly understood. Here, we report a novel, and selective, pattern of functional brain activity alteration in healthy young adult human APOE-ε4 carriers. Our findings suggest that APOE-ε4 may influence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26552581
DOI: 10.1038/srep16322
PMCID: PMC4639783

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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