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Article

APOE moderates compensatory recruitment of neuronal resources during working memory processing in healthy older adults.

Neurobiology of aging - 1 Aug 2017

Scheller Elisa, Peter Jessica, Schumacher Lena V, Lahr Jacob, Mader Irina, Kaller Christoph P, Klöppel Stefan

Abstract excerpt

The APOE ε4 allele increases the risk for sporadic Alzheimer's disease and modifies brain activation patterns of numerous cognitive domains. We assessed cognitively intact older adults with a letter n-back task to determine if previously observed increases in ε4 carriers' working-memory-related brain activation are compensatory such that they serve to maintain working memory function. Using multiple regression...

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Source

Identifiers

PMID: 28528773
DOI: 10.1016/j.neurobiolaging.2017.04.015

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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