Article
Effects of the apolipoprotein E ε4 allele on functional MRI during n-back working memory tasks in healthy middle-aged adults.
AJNR. American journal of neuroradiology - 1 Jan 2000
Chen C-J, Chen C-C, Wu D, Chi N-F, Chen P-C, Liao Y-P, Chiu H-W, Hu C-J
Abstract excerpt
BACKGROUND AND PURPOSE: APOE4 is the best-documented genetic risk factor for sporadic AD. Previous research showed that APOE4 is associated with increased risk of occurrence and earlier onset of AD in a gene dose-dependent manner. However, the specific role of APOE4 in processing of brain functions requires further investigation. Investigators have used fMRI to measure brain activity on the basis of the blood...
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